Concerns that Greece's negotiations with creditors may stall sent the markets plummeting to close sharply lower with the Dow collapsing 190 points to 18,041. Nasdaq dove 56 points to 5,032.

On the upside

Barron's initiated coverage of Vascular Biogenics (Nasdaq: VBLT) with a Buy rating and a $13 price target.

Shares of Baozun (Nasdaq: BZUN) continued rising after making its Nasdaq debut last Thursday.

Calcalist reported that Nice Systems engaged in negotiations to buy LivePerson (Nasdaq: LPSN).
 
On the downside

Shares of Qunar Cayman Islands (Nasdaq: QUNR) fell after Priceline (Nasdaq: PCLN) announced an additional $250 million investment into Qunar rival Ctrip.com (Nasdaq: CTRP).

Tuniu (Nasdaq: TOUR) widened first quarter losses prompting a downgrade.

Tata Motors (NYSE: TTM) disappointed with sharply lower fourth quarter earnings that missed expectations by a wide margin and cancelled its full year dividend.
 
In the broad market, declining issues outpaced advancers by a margin of nearly 4 to 1 on the NYSE and by more than 3 to 1 on Nasdaq. The broader S&P 500 plunged 21 points to 2104. Bitcoin held steady at $236.
Despite a stronger than expected increase in new home sales last month, the markets extended its losses during the midday with the Dow diving 189 points to 18,042. Nasdaq plunged 54 points to 5,034.

On the upside

Bargain hunters snapped up shares of FXCM (NYSE: FXCM).

Hot Topic will pay a premium of approximately $122 million to acquire Geeknet (Nasdaq: GKNT).

An affiliate of SFX Entertainment (Nasdaq: SFXE) chief executive Robert F.X. Sillerman will take the company private in a deal valued at approximately $774 million.
 
On the downside

Shares of Jumei International Holding (NYSE: JMEI) extended its losses.

Investors locked in profits on Shake Shack (NYSE: SHAK).

Concerns that Greece may not reach a deal to restructure its debt weighed down shares of National Bank of Greece (NYSE: NBG).
 
In the broad market, declining issues outpaced advancers by a margin of more than 4 to 1 on the NYSE and by 7 to 2 on Nasdaq. The broader S&P 500 tumbled 20 points to 2105. Bitcoin added $1 to $237.
The markets opened sharply lower with the Dow plummeting 122 points to 18,109 as crude oil prices continued to fall. Nasdaq tumbled 43 points to 5,046.

On the upside

Prima BioMed (Nasdaq: PBMD) reported positive data from a Phase II CAN-003 ovarian cancer clinical trial.

The Food and Drug Administration granted Fast Track designation to IntelliPharmaCeutics International's (Nasdaq: IPCI) abuse deterrent Rexista Oxycodone extended-release tablets.

McDermott International (NYSE: MDR) won a brownfield contract from Saudi Aramco.
 
On the downside

Investors locked in profits on Youku Tudou (NYSE: YOKU).

RBC Capital downgraded First Solar (Nasdaq: FSLR) from a Sector Perform to an Underperform rating.

Retreating gold prices weighed down shares of Barrick Gold (NYSE: ABX) and Kinross Gold (NYSE: KGC).
 
In the broad market, declining issues outpaced advancers by a margin of nearly 7 to 2 on the NYSE and by nearly 5 to 2 on Nasdaq. The broader S&P 500 dropped 14 points to 2112. Bitcoin added $1 to $237.

U. S. markets closed

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U. S. markets are closed for Memorial Day.
Retreating crude oil prices weighed the markets down to a lower close with the Dow dropping 53 points to 18,232. Nasdaq eased a point to 5,089.

On the upside

Canaccord Genuity upgraded ReWalk Robotics (Nasdaq: RWLK) from a Hold rating to a Buy rating.

E-Commerce China Dangdang (NYSE: DANG) will report first quarter earnings on May 28, 2015.

Bargain hunters lifted shares of Sarepta Therapeutics (Nasdaq: SRPT).
 
On the downside

Shares of China Information Technology (Nasdaq: CNIT) continued falling.

Profit taking weighed down shares of ChinaCache International (Nasdaq: CCIH).

Retreating crude oil prices weighed down shares of offshore drilling services provider SeaDrill (NYSE: SDRL).
 
In the broad market, declining issues outpaced advancers by a margin of more than 5 to 3 on the NYSE and by more than 9 to 7 on Nasdaq. The broader S&P 500 slipped 4 points to 2126. Bitcoin added $1 to $236.
Crude oil prices slipped to weigh the markets down during the midday with the Dow falling 55 points to 18,229. Nasdaq edged up a point to 5,091.

On the upside

Eagle Rock Energy Partners (Nasdaq: EROC) will merge with a subsidiary of Vanguard National Resources (Nasdaq: VNR).

Shares of Shopify (NYSE: SHOP) continued soaring.

Youku Tudou (NYSE: YOKU) stock extended its gains.
 
On the downside

Otonomy (Nasdaq: OTIC) reported disappointing results from a Phase 2b trial of its unilateral Meniere's disease treatment OTO-104.

Chardan Capital Markets initiated coverage of Esperion Therapeutics (Nasdaq: ESPR) with a Sell rating.

Marvell Technology Group (NYSE: MRVL) reported sharply lower first quarter earnings as revenue fell and forecast current quarter results below expectations.
 
In the broad market, declining issues outpaced advancers by a margin of more than 5 to 3 on the NYSE and by nearly 7 to 5 on Nasdaq. The broader S&P 500 slipped 3 points to 2127. Bitcoin added $1 to $236.
The market markets opened mixed with the Dow losing 19 points to 18,266 while Nasdaq rose 7 points to 5,098 as consumer prices edged up 0.1%.

On the upside

Shares of Oncothyreon (Nasdaq: ONTY) continued to climb.

AVEO (Nasdaq: AVEO) stock extended its gains.

Ctrip (Nasdaq: CTRP) acquired a 37.6% stake in eLong (Nasdaq: LONG).
 
On the downside

Viggle (Nasdaq: VGGL) priced its public offering of approximately 3.6 million common shares at the discounted price of $2.50 per share.

Jumei International (NYSE: JMEI) reported higher first quarter earnings and revenue but the stock price fell.

Aeropostale (NYSE: ARO) reported a larger than expected loss for the first quarter as revenue fell.
 
In the broad market, declining issues outpaced advancers by a margin of nearly 2 to 1 on the NYSE and by 5 to 4 on Nasdaq. The broader S&P 500 eased a point to 2129. Bitcoin held steady at $235.
The market closed flat with the Dow holding steady at 18,285 despite a greater than expected increase in first time applications for unemployment benefits. Nasdaq climbed 19 points to 5,090.

On the upside

Neostem (Nasdaq: NBS) received a $17.7 million grant from the California Institute for Regenerative Medicine.

Shares of Harvest Natural Resources (NYSE: HNR) rose again after reporting a narrower first quarter loss on Tuesday.

Covisint (Nasdaq: COVS) widened fourth quarter losses but revenue rose.
 
On the downside

Booz Allen Hamilton (NYSE: BAH) disappointed with lower fourth quarter earnings and revenue that fell short of analyst expectations.

Dicerna Pharmaceuticals (Nasdaq: DRNA) priced its public offering of 2.75 million common shares at the discounted price of $17.75 per share.

Chanticleer Holdings (Nasdaq: HOTR) widened losses for the first quarter.
 
In the broad market, advancing issues outpaced decliners by a margin of more than 7 to 5 on the NYSE and by more than 10 to 9 on Nasdaq. The broader S&P 500 rose 4 points to 2130. Bitcoin added $1 to $235.
Rebounding crude oil prices lifted the markets during the midday with the Dow rising 12 points to 18,298. Nasdaq gained 18 points to 5,090.

On the upside

Youku Tudou (NYSE: YOKU) widened losses for the first quarter but revenue climbed to top estimates.

Shares of PGA Holdings (NYSE: PGND) surged on its first trading day.

Trina Solar (NYSE: TSL) received the Innovation Award for its Duo-Max module at the Mexico International Renewable Energy Conference.
 
On the downside

Xunlei (Nasdaq: XNET) reported a loss for the first quarter as revenue fell.

Open Text (Nasdaq: OTEX) announced that president and chief executive Mark J. Barrenechea will resume full involvement in day-to-day operations of the company and that the company will restructure its business to support its Cloud strategy.

Bruker (Nasdaq: BRKR) chief financial officer Charles F. Wagner, Jr. resigned.
 
In the broad market, advancing issues outpaced decliners by a margin of more than 7 to 5 on the NYSE and by nearly 10 to 9 on Nasdaq. The broader S&P 500 rose 5 points to 2131. Bitcoin added $2 to $236.
Jobless claims rose more than expected last week but the markets opened flat with the Dow adding 2 points to 18,288 as crude oil prices rebounded. Nasdaq rose 8 points to 5,080.

On the upside

Shares of AVEO Pharmaceuticals (Nasdaq: AVEO) continued rising.

Minutes were published from the European Medicines Agency meeting when the Committee for Orphan Medicinal Products recommended orphan designation for Prana Biotech's (Nasdaq: PRAN) Huntington disease treatment PBT2.

Shares of Shopify (NYSE: SHOP) surged on its first trading day.
 
On the downside

Profit taking weighed down shares of Prima Biomed (Nasdaq: PBMD).

NetApp (Nasdaq: NTAP) disappointed with lower fourth quarter earnings and revenue that fell short of analyst expectations and forecast current quarter results below estimates prompting a downgrade.

Lumber Liquidators (NYSE: LL) chief executive Robert Lynch unexpectedly resigned.
 
In the broad market, advancing issues outpaced decliners by a margin of nearly 10 to 9 on the NYSE while decliners edged out advancers by nearly 5 to 4 on Nasdaq. The broader S&P 500 added 2 points to 2128. Bitcoin rose $2 to $236.

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